The Long Lab, at the Medical University of South CarolinaBRCA1 is an established tumor suppressor that plays a critical role in the development of both sporadic and hereditary breast and ovarian cancer. Considered a “master regulator” of genome integrity, BRCA1 has been linked to nearly all aspects of chromatin biology. Loss of BRCA1 is embryonic lethal and leads to cellular defects in stress signaling, DNA repair, cell cycle progression, apoptosis, chromatin condensation, and gene expression. Each of these processes involves dynamic changes in chromatin architecture that regulate spatial and temporal access to genomic DNA. Although implicated in various mechanisms of chromatin modification and remodeling, a mechanistic understanding of BRCA1’s role in regulating chromatin dynamics has been difficult to establish due to the global consequences of its dysfunction. Using Xenopus egg extracts, my lab seeks to understand how BRCA1 and other chromatin regulators mediate interactions between different biological processes as they compete for access to DNA.
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Recent AnnouncementsThe lab's paper was accepted to Nature Communications!
April 2022 Baicheng was awarded a fellowship from the Hollings Cancer Center!
March 2022 Colleen successfully defended her dissertation!
January 2022 Nancy accepted a position at Roche in Boston!
September 2021 The R35 MIRA was renewed for another 5 years!
June 2021 Colleen's review was accepted to Comprehensive Pharmacology!
May 2021 John successfully defended his dissertation!
May 2021 |
