The Long Lab, at the Medical University of South Carolina
BRCA1 is an established tumor suppressor that plays a critical role in the development of both sporadic and hereditary breast and ovarian cancer. Considered a “master regulator” of genome integrity, BRCA1 has been linked to nearly all aspects of chromatin biology. Loss of BRCA1 is embryonic lethal and leads to cellular defects in stress signaling, DNA repair, cell cycle progression, apoptosis, chromatin condensation, and gene expression. Each of these processes involves dynamic changes in chromatin architecture that regulate spatial and temporal access to genomic DNA. Although implicated in various mechanisms of chromatin modification and remodeling, a mechanistic understanding of BRCA1’s role in regulating chromatin dynamics has been difficult to establish due to the global consequences of its dysfunction. Using Xenopus egg extracts, my lab seeks to understand how BRCA1 and other chromatin regulators mediate interactions between different biological processes as they compete for access to DNA.
The lab's paper was accepted to Nature Communications!
Our collaborative paper with Dr. Delaney was accepted to NAR. PMID: 35380699
Baicheng was awarded a fellowship from the Hollings Cancer Center!
Colleen successfully defended her dissertation!
Nancy accepted a position at Roche in Boston!
Our collaborative paper with Dr. Howe was accepted to Life Science Alliance.
The R35 MIRA was renewed for another 5 years!
Colleen's review was accepted to Comprehensive Pharmacology!
John successfully defended his dissertation!
John's paper was accepted to NAR. PMID: 33660782