The Long Lab, at the Medical University of South CarolinaBRCA1 is an established tumor suppressor that plays a critical role in the development of both sporadic and hereditary breast and ovarian cancer. Considered a “master regulator” of genome integrity, BRCA1 has been linked to nearly all aspects of chromatin biology. Loss of BRCA1 is embryonic lethal and leads to cellular defects in stress signaling, DNA repair, cell cycle progression, apoptosis, chromatin condensation, and gene expression. Each of these processes involves dynamic changes in chromatin architecture that regulate spatial and temporal access to genomic DNA. Although implicated in various mechanisms of chromatin modification and remodeling, a mechanistic understanding of BRCA1’s role in regulating chromatin dynamics has been difficult to establish due to the global consequences of its dysfunction. Using Xenopus egg extracts, my lab seeks to understand how BRCA1 and other chromatin regulators mediate interactions between different biological processes as they compete for access to DNA.
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Recent AnnouncementsElizabeth was awarded a fellowship from the National Science Foundation (NSF)!
August 2024 Abby decided to join the lab as a new PhD student!
May 2024 Baicheng successfully defended his dissertation!
January 2024 Elizabeth decided to join the lab as a new PhD student!
May 2023 Julie was awarded a fellowship from the Hollings Cancer Center!
March 2023 Our collaborative paper with Dr. Gan was accepted to Science Advances!
December 2022 Colleen's paper was accepted to JBC!
November 2022 John's paper was accepted to Nature Communications!
May 2022 Our collaborative paper with Dr. Delaney was accepted to NAR!
April 2022 |
